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The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for...
The hallmark of B-cell development is the ordered recombination of immunoglobulin (Ig) genes. Recently, considerable progress has been achieved in assembling gene regulatory networks comprised of signaling components and transcription factors that regulate B-cell development. In this chapter we synthesize experimental evidence to explain how such signaling pathways and transcription factors can orchestrate...
Chapter Objectives: The purpose of this chapter is to stress the importance of the manufacturing strategy in the development of a competitive edge and to document the reasons for developing the AMBIT approach. Having read this chapter, the reader should become familiar with: • Porter’s five competitive forces. • The importance of the manufacturing strategy. Performance of the manufacturing...
Chapter Objectives: The purpose of this chapter is to introduce some of the analysis tools which can be used to support the manager or team of managers in evaluating the strategic effects of a particular technology and/or programme implementation and/or change. The tools used to illustrate the possible analysis approaches are; Analytic Hierarchy Process (AHP), Case Based Reasoning (CBR)...
Chapter Objectives: Management tools based on the AMBIT approach should be learning tools. In the design of an AMBIT software toolset, it is important to ensure that management learning is facilitated through the use of the tool. Thus, in this chapter we look at the theory of learning and that of creativity, and their impact on user interaction with IT tools. These areas need to be examined...
Chapter Objectives: All high-performance organisations, are, and must be, interested in developing and using effective performance measurement and performance measurement systems, as it isonly through such systems that these organisations can maintain their high-performance. The purpose of this chapter is to introduce the reader to performance measurement and some of the performance measurement...
Chapter Objectives: The purpose of this chapter is to show the reader how we can link technology and programme issues to the manufacturing strategy. In doing so, we are able to assess the strategic implications of changes. Having read this chapter, the reader should become familiar with: • The gap between strategic management and technology issues. • The derivation of key technology...
Chapter Objectives: Chapter Objectives: With the explosion of available information technology based products, the IT revolution has resulted in information accessible at our fingertips. The widespread access to this global information has resulted in increased competition and intensified the challenge for today’s organisations to survive and prosper. Complacency in the marketplace is no...
Chapter Objectives: The purpose of this chapter is to show the reader the linkage of the business goals, expressed in terms of the organisation’s critical success factors (CSFs) to the manufacturing strategy by means of the measures of manufacturing performance (MOMPs). Having read this chapter, the reader should become familiar with: • The AMBIT performance measurement framework, based...
Strategic Decision Making in Modern Manufacturing introduces and explains the AMBIT (Advanced Manufacturing Business ImplemenTation) approach, which has been developed to bridge the gap between strategic management considerations and the operational effects of technology investment decisions on the manufacturing organisation, so that the likely impact of new manufacturing technology and/or programme...
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