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The motility of the stomach is coordinated by an electrical activity termed “slow waves”, and slow-wave dysrhythmias contribute to motility disorders. One major method for clinically evaluating gastric dysrhythmias has been electrogastrography (EGG); however, the clinical utility of EGG is limited partly due to the uncertainty regarding its electrophysiological basis. In this study, a multiscale model...
Gastrointestinal slow waves are generated within networks of interstitial cells of Cajal (ICCs). In the intact tissue, slow waves are entrained to neighboring ICCs with higher intrinsic frequencies, leading to active propagation of slow waves. Degradation of ICC networks in humans is associated with motility disorders; however, the pathophysiological mechanisms of this relationship are uncertain....
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