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Background
Obesity associated with various complications has increased worldwide. Body weight gain alters lipid metabolites (especially sphingolipids) contributing to obesity‐induced inflammation. However, the significance of the metabolites in the development of obese asthma is not yet clear.
Methods
The serum levels of sphingolipids were measured using liquid chromatography‐tandem mass spectrometry...
Background
Asthma is associated with inflammatory dysregulation, but the underlying metabolic signatures are unclear. This study aimed to classify asthma inflammatory phenotypes based on cellular and metabolic features.
Methods
To determine cellular and metabolic profiles, we assessed inflammatory cell markers using flow cytometry, sphingolipid (SL) metabolites using LC‐MS/MS, and serum cytokines...
Background
Activated eosinophils release extracellular traps (EETs), which contribute to airway inflammation in severe asthma (SA). However, the role of EETs in innate immunity has not yet been completely determined. The present study aimed to demonstrate the mechanism of airway inflammation in SA mediated by EETs.
Methods
Peripheral counts of EET+ eosinophils and type 2 innate lymphoid cells (ILC2s)...
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