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Objective
Genetic studies have suggested that the branched‐chain amino acids (BCAAs) valine, leucine, and isoleucine have a causal association with type 2 diabetes (T2D). However, inferences are based on a limited number of genetic loci associated with BCAAs.
Methods
Instrumental variables (IVs) for each BCAA were constructed and validated using large well‐powered data sets and their association...
Objective
Weight regain occurs after medical weight loss via mechanisms of post‐weight‐loss “metabolic adaptation.” The relationship of inflammatory proteins with weight loss/regain was studied to determine a role for inflammation in metabolic adaptation.
Methods
Seventy‐four proteins central to inflammation and immune regulation (Olink) were analyzed in plasma from up to 490 participants in a...