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Seasonal changes in the isoform composition of thick and thin filament proteins (titin, myosin heavy chains (MyHCs), nebulin), as well as in the phosphorylation level of titin in striated muscles of brown bear ( Ursus arctos ) and hibernating Himalayan black bear ( Ursus thibetanus ussuricus ) were studied. We found that the changes that lead to skeletal muscle atrophy...
Using the real-time reverse-transcription polymerase chain reaction (RT-PCR) and low percentage SDS-gel electrophoresis, changes in the gene expression and isoform composition of a giant sarcomeric protein titin (connectin) in cardiac muscle and changes in its isoform composition in skeletal muscle m. soleus of chronically alcoholized rats were studied. The decreased content of titin protein in examined...
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