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The four principles of medical ethics – beneficence, nonmaleficence, autonomy, and justice – provide a pragmatic foundation and steadying influence to guide prescribing in older people where the evidence base for efficacy is uncertain and concerns regarding adverse drug reactions are protean. In most cases, the ethical principles are undermined not by intent, but more likely by lack of knowledge,...
Choosing the right medicine and dose regimen for the right patient are critical aspects of achieving quality use of medicines in older people. A comprehensive understanding of pharmacokinetics and pharmacodynamics is central to dose regimen design for older people. Ageing is associated with increased medication use and range of physiological changes that have the potential to effect drug pharmacokinetics...
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