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Gender differences and menopause are associated with the cognitive decline and pathogenesis of Alzheimer's disease (AD). Although deficits of subcortical–cortical loops have been implicated in AD, no study has directly examined the resting-state brain functional alterations in postmenopausal women with mild cognitive impairment (MCI).Forty-eight subjects were recruited, including 15 older females...
The outer mitochondria membrane 40 homolog (TOMM40) is thought to be involved in the mitochondrial function and to influence the susceptibility for the development of AD. To determine whether TOMM40 rs157581 polymorphism is a plausible modulator of spontaneous brain activity in amnestic mild cognitive impairment (aMCI) patients, 46 aMCI subjects and 21 healthy controls were recruited and explored...
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