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Abstract Serum from patients with scleroderma recognizes the clumpy autoantigen. The present studies addressed the issue as to whether the clumpy nucleolar autoantigen recognized by scleroderma serum is fibrillarin-U3 snoRNP. Clones encoding for clumpy autoantigen were immunodetected from a gt11 HeLa cell random-primed library with the serum from a patient with diffuse scleroderma and autoautoantibodies...
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