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Autophagy is an evolutionarily conserved process in eukaryotic cells to recycle damaged organelles, protein aggregates, and misfolded proteins, providing an efficient adaptive mechanism against inflicting environmental challenges, such as nutrient deprivation, hypoxia, and fluctuation in growth factor availability. Dysregulation of autophagy is an emerging mechanism of cancer cell resistance to treatment...
Because of their stimulating effect on manifold components of the innate immune system, TLR-agonists are in the focus of the search for potent drugs in combinational anticancer therapy. They induce the maturation and cross-priming of Dendritic Cells (DC), and have been shown to enhance Natural Killer (NK) cell dependent lysis of tumor cells in combination with monoclonal antibodies (mAb) such as anti-epidermal...
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