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Arsenic is a known human carcinogen. However, the mechanism of how arsenic induces cell transformation remains unclear. In this study, we demonstrated that long‐term exposure to sodium arsenite at low‐dose (2 µM) increases cell proliferation and neoplastic transformation in a mouse epidermal cell model, JB6 promotion‐susceptible cells. The phosphorylation of AKT and its downstream targets, 70‐kDa...
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