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The ubiquitin system has been recently implicated in various aspects of transcriptional regulation, including proteasome-dependent degradation of transcriptional activators. In yeast, the activator Met4 is inhibited by the SCF Met30 ubiquitin ligase, which recognizes and oligo-ubiquitylates Met4. Here, we demonstrate that in minimal media, Met4 is ubiquitylated and rapidly...
HIV-1 Vpu interacts with CD4 in the endoplasmic reticulum and triggers CD4 degradation, presumably by proteasomes. Human βTrCP identified by interaction with Vpu connects CD4 to this proteolytic machinery, and CD4-Vpu-βTrCP ternary complexes have been detected by coimmunoprecipitation. βTrCP binding to Vpu and its recruitment to membranes require two phosphoserine residues in Vpu essential for CD4...
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