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The Akt/mTOR and MAPK pathways play important roles in modulating cellular function in response to extracellular signals, and they are known to be activated in certain kinds of sarcomas. Few investigations have examined these pathways in dedifferentiated liposarcoma (DDLS), in relation to clinicopathological features. Clinicopathological and immunohistochemical analyses were conducted using 99 DDLS...
We established a dedifferentiated liposarcoma cell line (NDDLS‐1) that produces interleukin‐6 (IL‐6) and granulocyte‐colony stimulating factor (G‐CSF). The parental tumor showed high leukemoid reactions. The NDDLS‐1 cell line was established from a pleural effusion associated with a lung metastasis. Pleomorphic tumor cells arranged in a haphazard growth pattern were seen in xenograft tumors. Numerous...
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