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Although instrumental for optimizing their pharmacological activity, a molecular understanding of the preferential interactions given by volatile anesthetics is quite poor. This paper confirms the ability of halothane to work as a hydrogen‐bond (HB) donor and gives the first experimental proof that halothane also works as a halogen‐bond (HaB) donor in the solid state and in solution. A halothane/hexamethylphosphortriamide...
Halothan, ein häufig genutztes Anästhetikum, kann gleichzeitig als Wasserstoffbrücken‐ und Halogenbrückendonor im Festkörper und in Lösung fungieren, wie S. V. Rosokha, G. Resnati et al. in ihrer Zuschrift auf S. 12586 zeigen. Beide Wechselwirkungen involvieren funktionelle Gruppen, die auch in Zellmembranen vorhanden sind, wahrscheinlichen Zielstrukturen von Halothan im menschlichen Körper. Die Fähigkeit...
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