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In difluoromethylornithine-resistant L1210 cells stimulated to grow from quiescence, haloperidol caused an early and dose-dependent inhibition of the induction of ornithine decarboxylase (ODC) activity, with an IC 50 of 3.5 μM. This effect was accompanied by a reduction in the ODC mRNA level and inhibition of cell growth. Other σ ligands of different chemical classes inhibited the induction...
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