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Background Molecular changes associated with colorectal cancer (CRC) are detected by stool deoxyribonucleic acid testing but could persist following tumor resection. Aims We sought to determine whether methylated gene markers in stool normalize after CRC resection. Methods We studied stools from 22 CRC cases before and after subtotal resection and from 80 colonoscopy-normal controls. In blinded...
BACKGROUND:Pancreatic cancer (PanC) presents at late stage with high mortality. Effective early detection methods are needed. Aberrantly methylated genes are unexplored as markers for noninvasive detection by stool testing. The authors aimed to select discriminant methylated genes and to assess accuracy of these and mutant KRAS in stool to detect PanC.
METHODS:Nine target genes were assayed by real‐time...
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