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Voltage-gated Na + channels are regulated in response to oxygen deprivation in the mammalian cortex. Past investigations have demonstrated that Na + channel protein expression is up-regulated in the immature brain exposed to prolonged hypoxia. Since it is unknown as to which Na + channel subtype(s) is involved in this regulation, we used RT-PCR to assess the effect of hypoxia...
The contribution of cardiovascular activity in the early central responses to systemic inflammation was assessed in rats following intravenous administration of subseptic doses of lipopolysaccharide (LPS). LPS at 12.5 μg/kg increased heart rate (HR) but did not alter mean arterial pressure (MAP), and induced interleukin-1β (IL-1β) gene expression at 1 h in circumventricular organs (CVOs), choroid...
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