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Background
Using a functional analysis of prostate cancer cells, we found a CD24‐dependent inactivation of mutant p53, but the clinical significance of this observation remained uncertain. Here, we validated these results with samples of human prostate cancer and explored the role of a CD24‐p53 axis in racial disparities of prostate cancer.
Methods
Samples of formalin‐fixed, paraffin‐embedded prostate...
CD24 plays an oncogenic role in the onset and progression of various human cancers, including prostate cancer. In the present study, we identified two linkage disequilibrium blocks with four recombination hotspot motifs in human CD24 locus. To elucidate whether genetic variants of CD24 are associated with susceptibility to prostate cancer and its disease status, we conducted a case‐control association...
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