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Bloom syndrome protein (BLM) is a conserved RecQ family helicase involved in the maintenance of genome stability. BLM has been widely recognized as a genome “caretaker” that processes structured DNA. In contrast, our knowledge of how BLM behaves on single‐stranded (ss) DNA is still limited. Here, we demonstrate that BLM possesses the intrinsic ability for phase separation and can co‐phase separate...
Bloom syndrome protein (BLM) is a conserved RecQ family helicase involved in the maintenance of genome stability. BLM has been widely recognized as a genome “caretaker” that processes structured DNA. In contrast, our knowledge of how BLM behaves on single‐stranded (ss) DNA is still limited. Here, we demonstrate that BLM possesses the intrinsic ability for phase separation and can co‐phase separate...
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