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A rapid preparation of compounds (1–24), with the objective of discovering novel and potent anti-inflammatory agent. All the compounds exhibited anti-inflammatory and analgesic activities at the dose 50mg/kg p.o. The compound 1-(2′,4′-Chloroacridine-9′-yl)-3-(5′-pyridine-4-yl)-(1,3,4-oxadiazol-2-yl-thiomethyl)-pyrazole-5-one 24 showed better anti-inflammatory and analgesic activities at the three...
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