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The stabilities, structures, and functions of nucleic acids are responsive to surrounding conditions. Living cells contain biomolecules, including nucleic acids, proteins, polysaccharides, and other soluble and insoluble low-molecular weight components, that occupy a significant fraction of the cellular volume (up to 40%), resulting in a highly crowded intracellular environment. We have proven that...
The thermodynamic parameters of an antiparallel G-quartet formation of d(G 4 T 4 G 4 ) with 1 mM divalent cation (Mg 2+ , Ca 2+ , Mn 2+ , Co 2+ , and Zn 2+ ) were obtained. The thermodynamic parameters showed that the divalent cation destabilizes the antiparallel G-quartet of d(G 4 T 4 G 4...
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