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In nanofluidic resistive pulse sensing (RPS) platforms, particles pass through a nanopore by an external electric field. If particles pass through the immiscible liquid‐liquid interface formed inside a pore, the effective volume is increased with conformal coating and the translocation speed is decreased by the interfacial tension of the interface. Therefore, both the resistive pulse signal and the...
Nanofluidic resistive pulse sensing (RPS) has been extensively used to measure the size, concentration, and surface charge of nanoparticles in electrically conducting solutions. Although various methods have been explored for improving detection performances, intrinsic problems including the extremely low particle‐to‐pore volume ratio (<0.01%) and fast nanoparticle translocation (10–1000 µs) still...
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