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Spatial resolution is one of the most important performance in PET system. Higher spatial resolution can give more information about the region of interest in animal PET imaging. In this work, we implement a high resolution (approximate 0.7 mm) all digital animal PET system using improved Trans-PET detectors. The improved detector module uses 24×24 crystal array for higher intrinsic spatial resolution...
The hexagonal prism shaped crystal shows potential to design a PET system for its higher ray blocking efficiency and equidistance with neighbors. This paper proposed a honeycomb PET based on hexagonal prism shaped scintillation crystals. Its performance was evaluated and compared with a traditional PET system based on rectangular prism shaped crystals by GEANT4 simulation. The results show that the...
With high specificity of tumor necrosis, hypoxia tissues and subclinical lesions, PET may have great potential for tumor surgery guidance. PET images in surgery will tell us how tissues change during the operation and whether the lesion has been cleared. We did research on panel PET guided therapy, and we have developed 3-dimensional reconstruction methods for panel PET systems. However we meet the...
In recent years, panel PET is an interesting field in medical imaging. But the major obstacle of panel PET is the limited view problem. Images reconstructed by traditional algorithms will suffer serious artifacts. Time-of-flight (TOF) information can be incorporated into the image reconstruction to remove the artifacts. However, the best system timing resolution available in current commercial PET...
In this work, we have characterized the detection limit and quantitative accuracy of the Trans-PET® BioCaliburn1® LH system, in order to evaluate the feasibility of using small animal PET in in vitro studies. An in vitro cell uptake experiment with radioactivity lower than 1 μCi was performed with Monte Carlo (MC) simulation and then verified in real world experiments. Radioactivity concentrations...
Recently, there is growing interest in directly digitizing the scintillation pulses in PET detectors. With digital pulse samples, in principle one can apply nontrivial signal analysis software algorithms to either yield better detection performance or more flexibility in detector design. Previously, we have proposed the MVT method for direct scintillation pulse sampling and developed several kinds...
A combined Cerenkov Luminescence Imaging (CLI) and Positron Emission Tomography (PET) scanner for in-vivo imaging of small animals is conceptually designed via all event-by-event readout and multiple-coincidence processing. Strategies and concepts for the design of the combined CLI/PET scanner based on the list-mode scheme are analyzed and modeled in terms of Monte Carlo approach. This allows for...
Based on the multi-voltage threshold (MVT) method, we have proposed the FPGA-only implementation for positron emission tomography (PET) detectors. It realizes required comparators and time-to-digital convertors (TDCs) on FPGAs. Thus, its performance can be easily enhanced by optimizing the inside algorithm without hardware modifications or improved with the development of FPGA technologies. In this...
In our previous work, we have proposed a stationary panel positron emission tomography (PET) for human body imaging. Besides the large solid angle, the panel PET also provides an open geometry which allows other operations being performed simultaneously during a PET scanning. However, the main challenge of panel PET is the limited view problem. Images reconstructed using traditional algorithms will...
Respiratory motion is an image degradation factor in thoracic Position Emission Tomography (PET) imaging. A primary step in the majority of motion compensation approaches is gating. Unfortunately, gating usually requires an extra hardware device, which usually is unfamiliar to the medical staff making the procedure complex and error prone, and therefore, uncommon clinical practice. The primary objective...
Nowadays, time-of-flight (TOF) PET detectors and systems are becoming increasingly common since scintillators, photodetectors and electronics has made significant progress. It has been well recognized that TOF PET imaging can increase the image signal-to-noise ratio (SNR) and yield other benefits; and the degree of these enhancements is higher as the timing resolution improves. Previously we have...
As digital signal has abilities like immunity for transmit distortion and feasibility to calibrate, digital architecture that samples the event waveform at the earliest possible stage shows promising potential for building next generation PET system. Multi-voltage threshold (MVT) is a digital sampling method that take time samples when pulses cross predefined thresholds and extracts event information...
We proposed a novel Event Pulses Classification (EPC) method to reject scatter directly from Multi-Voltage Threshold (MVT) samples data. This study is motivated by the emerging demand for the MVT-digitalized scintillation pulses processing in the PET implementation. MVT is a sparse-quantization-level flash ADC which can digitize fast signals (such as scintillation pulses without shaper) with excellent...
The all digital PET system is attracting more and more attentions due to its flexibility, scalability, reusability and upgradability. Based on the Trans-PET formerly developed by us, we are trying to fulfill online parameter calibration of the all digital PET system. The ability of thorough and quick online parameter calibration will make the system well adaptive to application variation, environment...
We are developing, at the Huazhong University of Science and Technology, a small-animal positron emission tomograph (PET) scanner that has two new features. Firstly, it uses detector modules that are based on a new digital readout electronics previously investigated and reported by us. Secondly, it can arrange the detector modules into various scanner geometries for different imaging needs. In this...
An all-digital positron emission tomography (PET) scanner for imaging small animals has been developed at Huazhong University of Science and Technology (HUST). The implementation of block detector with position sensitive photomultiplier (PSPMT) and multi-voltage threshold (MVT) technology is presented in this paper. The detector comprises 12 basic detector modules (BDMs), which can be used to construct...
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