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Acute‐on‐chronic liver failure (ACLF) is a progressive disease that is associated with rapid worsening of clinical symptoms and high mortality. A multicentre prospective study from China demonstrated that patients with hepatitis B virus‐related ACLF (HBV‐ACLF) exhibited worse clinical characteristics and higher mortality rates compared to non‐HBV‐ACLF patients. Immune dysregulation is closely linked...