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Dihydrofolate reductase (DHFR) is an essential enzyme in the folate metabolism pathway and an important target of antineoplastic, antimicrobial, antiprotozoal, and antiinflammatory drugs. Despite the clinical effectiveness of current antifolate treatments, new drugs are needed to be designed due to developing resistance of this enzyme through multiple‐site mutagenesis. Understanding the factors affecting...
Comparative molecular field analysis (CoMFA) studies have been carried out on 2,4‐diamino‐5‐(2_‐arylpropargyl)pyrimidine derivatives such as dihydrofolate reductase (DHFR) anticancer inhibitors. Because of the interoperable results of CoMFA models, they are noteworthy tools in rational drug designs. However, the huge amount of fields generated by this method contributes to its poor predictive ability...
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