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Background
Head and neck squamous cell carcinoma (HNSCC) is a debilitating disease with poor survival. Although epidermal growth factor receptor (EGFR)‐targeting antibody cetuximab improves survival in some settings, responses are limited suggesting that alternative approaches are needed.
Methods
We performed a high throughput drug screen to identify EGFR inhibitor‐based synergistic combinations...
Cover Image: The cover image is based on the Research Article Small molecule profiling to define synergistic EGFR inhibitor combinations in head and neck squamous cell carcinoma by Chad Brenner et al., https://doi.org/10.1002/hed.27018.
Background
Laryngeal squamous cell carcinomas (LSCCs) have a high risk of recurrence and poor prognosis. Patient‐derived cancer cell lines remain important preclinical models for advancement of new therapeutic strategies, and comprehensive characterization of these models is vital in the precision medicine era.
Methods
We performed exome and transcriptome sequencing as well as copy number analysis...
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