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Fabrication of nanozyme with catecholase‐like catalytic activity faces the great challenge of merging outstanding activity with low cost as well as simple, rapid, and low‐energy‐consumed production, restricting its industrial applications. Herein, an inexpensive yet robust nanozyme (i.e., DT‐Cu) via simple one‐step coordination between diaminotriazole (DT) and CuSO4 within 1 h in water at room temperature...
Heterostructured materials integrate the advantages of adjustable electronic structure, fast electron/ions transfer kinetics, and robust architectures, which have attracted considerable interest in the fields of rechargeable batteries, photo/electrocatalysis, and supercapacitors. However, the construction of heterostructures still faces some severe problems, such as inferior random packing of components...
Hypoxic Tumor Therapy
In article number 2200786, Lili Feng, He Ding, Piaoping Yang, and co‐workers develop a near‐infrared (NIR)–triggered nanoplatform with controlled release of a heat shock proteins (HSPs) inhibitor for synergistic mild photothermal and enhanced Fenton nanocatalysis. Upon NIR irradiation, gambogic acid is released and inhibits the expression of HSP90. Notably, the nanoplatform simultaneously...
Mild photothermal therapy (PTT, <45 °C) can prevent tumor metastasis and heat damage to normal tissue, compared with traditional PTT (>50 °C). However, its therapeutic efficacy is limited owing to the hypoxic tumor environment and tumor thermoresistance owing to the overproduction of heat shock proteins (HSPs). Herein, a near‐infrared (NIR)‐triggered theranostic nanoplatform (GA‐PB@MONs@LA)...
Multimodal synergistic therapy based on photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT) has attracted increasing attention in cancer therapy. However, the scant therapeutic efficiency is always a barrier for further application. Herein, a smart tumor microenvironment (TME) responsive nanocatalysts are developed by adopting Fe–Mn layered double hydroxides (FeMn‐LDH)...
It is absolutely imperative for development of material science to adjust upconversion luminescence (UCL) properties of highly doped upconversion nanoparticles (UCNPs) with special optical properties and prominent application prospects. In this work, featuring NaHoF4@NaYbF4 (Ho@Yb) structures, sub‐30 nm core–multishell UCNPs are synthesized with a small NaHoF4 core and varied Gd3+/Yb3+ coexisting...
Here a multifunctional nanoplatform (upconversion nanoparticles (UCNPs)‐platinum(IV) (Pt(IV))‒ZnFe2O4, denoted as UCPZ) is designed for collaborative cancer treatment, including photodynamic therapy (PDT), chemotherapy, and Fenton reaction. In the system, the UCNPs triggered by near‐infrared light can convert low energy photons to high energy ones, which act as the UV–vis source to simultaneously...
The low reactive oxygen species production capability and the shallow tissue penetration of excited light (UV) are still two barriers in photodynamic therapy (PDT). Here, Au cluster anchored black anatase TiO2−x nanotubes (abbreviated as Au25/B‐TiO2−x NTs) are synthesized by gaseous reduction of anatase TiO2 NTs and subsequent deposition of noble metal. The Au25/B‐TiO2−x NTs with thickness of about...
Near infrared (NIR) light triggered phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) affords superior outcome in cancer treatment. However, the reactive oxygen species (ROS) generated by NIR‐excited upconversion nanostructure is limited by the feeble upconverted light which cannot activate PDT agents efficiently. Here, an IR‐808 dye sensitized upconversion nanoparticle...
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