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Previous studies have proposed that albuminuria is involved in the activation of intrarenal renin angiotensin system (RAS), while its potential mechanism is still unclear. We investigated the influence of albumin on the expression of ACE/ACE2 and generation of Ang II in HK2 cells.The mRNA and protein expression of ACE and ACE2 was determined by RT-PCR and western blot respectively. Cellular localization...
There is an increasing prevalence of chronic kidney disease (CKD) worldwide. However, the exact incidence of CKD in China is still uncertain. In this cross-sectional study, we retrospectively investigated the prevalence and distribution of CKD in Chinese hospitalized adult patients.Totally 13,383 adult patients who were hospitalized at our hospital were included in this study. They included 6215 males...
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