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The ability to detect noxious stimuli and evoke a defensive response is made possible by specialized peripheral sensory neurons called nociceptors that respond to stimuli such as extreme temperature, pressure and injury. A number of experimental studies have been done on nociceptors at various range of temperatures in order to understand the underlying biophysical mechanisms. Simple models for describing...
We have studied the influence of temperature and ARL 67156 on ATP hydrolysis in mouse and guinea pig vas deferens in order to explore the properties of the enzymatic inactivation mechanism proposed to regulate purinergic neurotransmission at the sympathetic neuromuscular junction of smooth muscle. The ectonucleotidase activity was determined by using the malachite green method to measure the inorganic...
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