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Tomographic reconstruction of fluorescence optical projection tomography (OPT) data is usually performed using the standard filtered back projection (FBP) algorithm. However, there are several physical aspects of fluorescence OPT that pose major challenges for the FBP algorithm. These include blurring, and the fact that for an isotropically emitting point source (or fluorophore), the power received...
We present a new reconstruction algorithm for emission and transmission tomography. The algorithm performs maximum likelihood reconstruction and doubly stochastic segmentation simultaneously. The resulting reconstructions show promising edge-preservation as well as suppression of measurement noise.
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