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The effect of immunoinflammation on bone repair during the recovery process of bone defects needs to be further explored. It is reported that Mg2+ can promote bone repair with immunoregulatory effect, but the underlying mechanism on adaptive immunity is still unclear. Here, by using chitosan and hyaluronic acid‐coated Mg2+ (CSHA‐Mg) in bone‐deficient mice, it is shown that Mg2+ can inhibit the activation...
The emergent electronic, spin, and other quantum properties of 2D heterostructures of graphene and transition metal dichalcogenides are controlled by the underlying interlayer coupling and associated charge and energy transfer dynamics. However, these processes are sensitive to interlayer distance and crystallographic orientation, which are in turn affected by defects, grain boundaries, or other nanoscale...
Immunotherapy is a promising cancer therapeutic strategy. However, the “cold” tumor immune microenvironment (TIME), characterized by insufficient immune cell infiltration and immunosuppressive status, limits the efficacy of immunotherapy. Tumor vascular abnormalities due to defective pericyte coverage are gradually recognized as a profound determinant in “cold” TIME establishment by hindering immune...
Tumor Immunotherapy
Tumor vascular abnormalities is a profound determinant in the “cold” tumor immune microenvironment establishment by hindering immunotherapy efficacy. PDGFB@ZIF8‐RGD effectively induced tumor vascular normalization, by reprogramming the “cold” TIME to a “hot” tumor immune microenvironment and facilitated robust antitumor immunity. More in article number 2308638, Yongquan Qu, Jie...
Ocean energy is a kind of clean and renewable energy source, but it cannot be efficiently harvested by traditional electromagnetic generators, due to its low‐frequency characteristic. The emergence of triboelectric nanogenerators provides a more promising technology for collecting ocean energy. In this work, a durable roller‐based swing‐structured triboelectric nanogenerator (RS‐TENG) is designed...
Developing efficient and low‐cost noble‐free metal electrocatalysts is an urgent requirement. Herein, a one‐step, solid‐state template‐assisted method for fabricating isolated half‐metallic diatomic M, Zn─N─C (M═Fe, Co, and Ni) catalysts is reported. In particular, the fabricated Fe, Zn─N─C structure exhibits superior oxygen reduction reaction capabilities with a half‐wave potential of 0.867 V versus...
Blood–Brain Barrier Therapy
The blood–brain barrier (BBB) is a bottleneck in the treatment of brain tumors. In article number 2203678, Liang Wang, Yinyan Wang, Lin Feng, and co‐workers summarize the current approaches to overcome the BBB, such as the use of “Trojan horse” molecular modifications for deception, and describe a variety of micro‐nanocarriers for targeted brain tumor therapy.
The greatest obstacle to using drugs to treat brain tumors is the blood‐brain barrier (BBB), making it difficult for conventional drug molecules to enter the brain. Therefore, how to safely and effectively penetrate the BBB to achieve targeted drug delivery to brain tumors has been a challenging research problem. With the intensive research in micro‐ and nanotechnology in recent years, nano drug‐targeted...
Phototherapy is a promising treatment method for cancer therapy. However, the various factors have greatly restricted phototherapy development, including the poor accumulation of photosensitizer in tumor, hypoxia in solid tumor tissue and systemic phototoxicity. Herein, a mitochondrial‐targeted multifunctional dye‐anchored manganese oxide nanoparticle (IR808@MnO NP) is developed for enhancing phototherapy...
Researchers have devoted a lot of efforts on pursuing light weight and high flexibility for the wearable electronics, which also requires the related energy harvesting devices to have ultrathin thickness and high stretchability. Hence, an elastic triboelectric nanogenerator (TENG) is proposed that can serve as the second skin on human body. The total thickness of this TENG is about 102 µm and the...
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