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Neuropeptide Y (NPY) is associated with the aging process: transgenic rats overexpressing NPY live longer, while NPY Y2-receptor knockout (KO) mice show a decline in cognitive function.NPY is critical for the beneficial effects of caloric restriction: caloric restriction does not increase lifespan in NPY-KO mice.NPY is a mediator of nutrient-sensing pathways in the hypothalamus, a brain region with...
Since NPY increases endothelial cell (EC) stickiness for leukocytes, we studied the effects of LPS, TNF-α and IFN-γ on its expression and action in HUVEC. Cytokines raised NPY and pro-NPY intracellular content and dipeptidyl peptidase IV (DPP IV) activity. Y1 and Y2 receptors were expressed in basal conditions, and LPS, TNF-α and IFN-γ induced Y5 receptor expression with a concomitant extinction of...
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