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From Nov. 1990 to Oct. 1994 a total of 97 (72% pretreated) adults with locally-advanced, nonmetastastic soft tissue sarcomas were entered in a protocol (RHT-91) involving regional hyperthermia (RHT) combined with systemic preoperative chemotherapy followed by surgery. Primary tumor grading (84 patients had grade II or III), tumor size (>8cm) and/or extracompartmental tumor extension (46 patients),...
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