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Ventricular fibrillation and sudden cardiac death are two of the most dangerous complications of coronary heart disease and severe stress. The aim of the present paper is the evaluation of principle possibility of application of μ, κ and σ receptor ligands for correction of heart electrical instability induced by immobilisation stress (24 hrs).Heart electrical stability was evaluated using the electrical...
The aim of the present study is to examine the possible role of the peripheral μ-opioid receptors in the mechanisms of regulation of heart resistance to arrhythmogenic influences.It has been found that peripheral μ-receptor agonists DALDA and PL017 increased heart resistance to ischemic, reperfusion, epinephrine-, aconitine- and CaCL 2 -induced arrhythmias and also increased ventricular fibrillation...
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