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A main role for interleukin-4 (IL-4) is in humoral immunity, and follicular helper CD4 + T (Tfh) cells may be an intrinsic IL-4 source. Here we demonstrate that conserved noncoding sequence 2 (CNS2) is an essential enhancer element for IL-4 expression in Tfh cells but not in Th2 cells. Mice with a CNS2 deletion had a reduction in IgG1 and IgE production and in IL-4 expression in Tfh cells...
To understand how CD8 expression is regulated during the transition process from CD4 + 8 + (CD4 and CD8 double positive, DP) to CD4 − 8 + (CD8 single positive, CD8SP) cells in the thymus, the involvement of Runx proteins in the alteration of chromatin configuration was investigated. Using the chromatin immunoprecipitation assay, we first demonstrated that Runx proteins...
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