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A series of new 1,3,4-oxadiazole derivatives (6a–6x) containing pyridine and acylhydrazone moieties were synthesized and developed as potential telomerase inhibitors. The bioassay tests demonstrated that compounds 6n, 6o, 6q, 6s and 6t exhibited significant broad-spectrum anticancer activity with IC 50 range from 0.76 to 9.59μM against the four cancer cell lines (HEPG2, MCF7, SW1116 and BGC823)...
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