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To clarify the role of Angiotensin II in the regulation of peripheral sensory and motor systems, we initiated a study of the expression, localization and transport of Angiotensin II receptor types in the rat sciatic nerve pathway, including L 4 –L 5 spinal cord segments, the corresponding dorsal root ganglia (DRGs) and the sciatic nerve. We used quantitative autoradiography for AT...
Modafinil is a well-known psychoactive drug used to treat narcolepsy, hypoglycemia, cerebral ischemia and Parkinson's disease. Previous studies showed that ATP-sensitive potassium channels (K ATP ) play a key role in response to cerebral ischemia, hypoglycemia or metabolic inhibition. Modafinil (0.01–1 mM) dose-dependently decreased the GABA-activated currents (I GABA ). Pretreatment...
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