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Purpose The aim of this study was to investigate the safety and pharmacokinetics of motesanib (AMG 706), a small-molecule antagonist of vascular endothelial growth factor receptors 1, 2, and 3, platelet-derived growth factor receptor, and c-Kit in Japanese patients with advanced solid tumors. Methods Patients were administered motesanib orally once daily (QD) at doses of 50, 100, and 125 mg QD....
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