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The polymorphisms rs3758391 and rs1800470 located in SIRT1 and TGF‐β1 have been associated with type 2 diabetes in different populations but its functional effect is not clear. In this study, we evaluated their effect on the expression of SIRT1 and TGF‐β1 in peripheral blood as well as their participation in the formation of DNA–protein complexes in a pancreas‐derived cell line. It has been described...
Type 2 diabetes (T2D) is a chronic degenerative disease that involves the participation of several genetic and environmental factors. The objective of the study was to determine the association of the IRS1 (rs1801278), CAPN10 (rs3792267), TCF7L2 (rs7903146 and rs12255372), and PPARG (rs1801282) gene polymorphisms with T2D, in two different Mexican populations. We conducted a case‐control replication...
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