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To develop novel antimicrobial peptides (AMPs) with shorter lengths, improved prokaryotic selectivity and retained lipolysaccharide (LPS)-neutralizing activity compared to human cathelicidin AMP, LL-37, a series of amino acid-substituted analogs based on IG-19 (residues 13–31 of LL-37) were synthesized. Among the IG-19 analogs, the analog a4 showed the highest prokaryotic selectivity, but much lower...
To develop novel antimicrobial peptides (AMPs) with improved cell selectivity and potent LPS-neutralizing activity, we synthesized an 18 N-terminal residues peptide (BAMP-18) of bovine myeloid antimicrobial peptide-27 (BMAP-27) and its analogs (BMAP-18-W, BMAP-18-L, BMAP-18-I and BMAP-18-f). BMAP-18 and its analogs displayed much higher cell selectivity (about 4–97-fold increased) as compared to parental...
In this study, we investigated the mammalian cell toxicity and candidacidal mechanism of Arg- or Lys-containing Trp-rich model antimicrobial peptides (K 6 L 2 W 3 and R 6 L 2 W 3 ) and their d-enantiomeric peptides (K 6 L 2 W 3 -d and R 6 L 2 W 3 -d). Arg-containing peptides were more toxic to human erythrocytes...
To investigate the effect of the number and distribution of d-amino acids introduced into non-cell-selective α-helical antimicrobial peptides on the cell selectivity, protease stability and anti-inflammatory activity, we synthesized an 18-meric Leu/Lys-rich α-helical model peptide (K 9 L 8 W) and d-amino acid-containing diastereomeric peptides. Increasing in cell selectivity of the...
Indolicidin (IN) is a 13-residue Trp-rich antimicrobial peptide isolated from bovine neutrophils. To develop novel IN-derived antimicrobial peptides with enhanced cell specificity (therapeutic index) and potent anti-inflammatory activity, several IN analogs were synthesized by Pro→Lys substitution. All IN analogs displayed an increase in therapeutic index by 3- to 15-fold relative to parental IN....
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