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We investigated the mechanism of candidacidal action of a Lys/Leu‐rich α‐helical model antimicrobial peptide (K9L8W) and its diastereomeric peptide (D9‐K9L8W) composed of D,L‐amino acids. K9L8W killed completely Candida albicans within 30 min, but D9‐K9L8W killed only 72% of C. albicans even after 100 min. Tryptophan fluorescence spectroscopy indicated that the fungal cell selectivity of D9‐K9L8W...
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