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The antiapoptotic molecule Bcl‐2 inhibits apoptosis by preventing cytochrome c release from mitochondria. Although several studies have indicated the importance of Bcl‐2 in maintaining skeletal integrity, the detailed cellular and molecular mechanisms remain elusive. Since Bcl‐2−/− mice die before six weeks of age on account of renal failure and cannot be compared to adult wild‐type mice, we generated...
Skeletal mineralization is an important step regulating the mechanical properties of the calcified tissues, but molecular events underlying mineralization still remain elusive. We examined the role of extracellular signal-regulated kinase (Erk) pathways in matrix mineralization of osteogenic cells both in vitro and in vivo. Matrix mineralization by preosteocytic MLO-A5 cells and osteoblastic MC3T3-E1...
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