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Spannungsabhängige Natriumkanäle (Nav) sind für die Generierung und Weiterleitung von Aktionspotentialen in erregbaren Zellen, und somit auch für die Funktion sensibler Nerven, verantwortlich. In den letzten 20 Jahren konnten drei Nav-Untereinheiten in sensorischen Afferenzen identifiziert werden, Nav1.7, Nav1.8 und Nav1.9, denen eine spezifische Rolle für die Funktion nozizeptiver Neurone zugesprochen...
A local elevation of H + -ion concentrations often occurs in inflammation and usually evokes pain by excitation of primary nociceptive neurons. Expression patterns and functional properties of the capsaicin receptor and acid-sensing ion channels suggest that they may be the main molecular substrates underlying this proton sensitivity. Here, we asked how the capsaicin receptor TRPV1 and acid-sensing...
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