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In article number 2004385, Dan Shao, Kam W. Leong, Wen‐fei Dong, and co‐workers present cancer‐cell‐membrane‐coated mesoporous organosilica nanoparticles for radiation‐responsive drug delivery and cancer chemo‐immunotherapy. Under low‐dose X‐ray radiation, such biomimetic nanotherapeutics exhibit degradation‐controlled drug release and induced stronger antitumor immune responses, leading to enhanced...
Chemotherapy causes off‐target toxicity and is often ineffective against solid tumors. Targeted and on‐demand release of chemotherapeutics remains a challenge. Here, cancer‐cell‐membrane‐coated mesoporous organosilica nanoparticles (MONs) containing X‐ray‐ and reactive oxygen species (ROS)‐responsive diselenide bonds for controlled release of doxorubicin (DOX) at tumor sites are developed. DOX‐loaded...
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