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Poor water solubility limits the clinical use of andrographolide and its derivatives. In an attempt to develop potent hepatoprotective drugs, a strategy was proposed to improve the aqueous solubility of andrographolide. Ten andrographolide derivatives were designed, synthesized, evaluated for aqueous solubility and in vivo hepatoprotective activity against CCl4‐induced liver injury in mice. As expected,...
In an attempt to develop potent anti‐HIV drugs, 20 andrographolide derivatives were designed, synthesized, and evaluated for their in vitro anti‐HIV activity. The screening results revealed that five compounds showed potent anti‐HIV activities with therapeutic indices (TI) above 10. The most promising compound 6f shows a significant TI close to 34.07, with the potency to be a new lead.
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