The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Modulating microglial polarization is a potential strategy to assuage secondary brain injury caused by intracranial hemorrhage (ICH). However, despite decades of effort, effective therapies targeting microglia for ICH are still lacking. Here, a nanorobotic, tetrahedral framework nucleic acid (tFNA), is successfully synthesized and designed to carry C‐C chemokine receptor 2 (siCCR2) for use in in vitro...
Tetrahedral Framework DNA
In article number 2101435, Chao You, Yunfeng Lin, and co‐workers design a nanomaterial (tetrahedron framework nucleic acid, tFNA) to carry siCCR2 that could promote hematoma absorption by regulating microglia polarization from the M1 toward M2 subtype during the acute phase of intracranial hemorrhage. The tFNA‐siCCR2 provide a novel therapeutic strategy for protecting neurological...