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Front Cover: In this study, a kind of PLGA cage‐like structures loaded with Sr‐ and Mg‐doped HA (Sr/Mg@HA/PLGA‐CAS) was prepared. The multifunctional Sr/Mg@HA/PLGA‐CAS porous system improved cell adhesion, osteogenic differentiation and angiogenic differentiation. Meanwhile, Sr/Mg@HA/PLGA‐CAS inhibited osteoclast differentiation, and had a potential contribution to the repair of osteoporotic bone...
Poly(lactic‐co‐glycolic acid) (PLGA)‐based porous structures have a widespread application in bone defects. To solve its flaws in the bone application, hydroxyapatite (HA) is often introduced into PLGA‐based systems, and ion doping endows HA with more biological activity. In osteoporotic bone defects, the decreased activity of osteoblasts and the hyperactive osteoclasts results in slow bone repair...