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Human CNOT6L/CCR4, a member of the endonuclease‐exonuclease‐phosphatase (EEP) family enzymes, is one of the two deadenylase enzymes in the conserved CCR4‐NOT complex. Here, we report inhibitor‐bound crystal structures of the human CNOT6L nuclease domain in complex with the nucleotide CMP and the aminoglycoside neomycin. Deadenylase activity assays show that nucleotides are effective inhibitors of...
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