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Parkinson’s disease (PD) is a neurodegenerative disease. Nicotine has been reported to have the role in preventing Parkinson’s disease. However, its mechanism is still unclear. In present study we found that nicotine suppressed 1-methyl-4-phenylpyridinium ion(MPP+) toxicity in PC12 cells by MTT assay. The expression of thioredoxin-1(Trx-1) was decreased by MPP+, which was restored by nicotine. The...
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