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Excitotoxic insults such as cerebral ischemia are thought to enhance neuronal autophagy, which is then thought to promote neuronal cell death. Excitotoxic insults indeed increase autophagy markers. Notably, however, autophagy markers can be increased either by autophagy induction (as this enhances their production) or by late-stage autophagy inhibition (as this prevents their degradation during autophagic...
αKAP is an anchoring protein for the Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) and is encoded within the same gene as the CaMKIIα isoform. αKAP co-assembles with CaMKII and targets such heteromers to the membrane of the sarcoplasmic reticulum, where CaMKII can regulate Ca 2+ homeostasis. CaMKII has also nuclear functions in skeletal muscle, however, the nuclear targeting...
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