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The use of an optical resolution photoacoustic microscopy (OR‐PAM) system to evaluate the vascular disruptive effect of combretastatin A4 Phosphate (CA4P) on a murine orthotopic glioma with intact skull is described here. Second generation optical‐resolution photoacoustic microscopy scanner with a 532 nm pulsed diode‐pumped solid‐state laser that specifically matches the absorption maximum of hemoglobin...
Optical resolution photoacoustic microscopy (OR‐PAM) imaging system is exploited to evaluate the vascular disruptive effect of Combretastatin A4 Phosphate (CA4P), a solid tumor drug, on a murine orthotopic glioma with intact skull. Hemodynamic changes in tumor vasculature are in agreement with the well documented shutdown and recovery associated CA4P administration. High resolution vasculature images...
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